Dna microarray technology provides a means to examine large numbers of molecular changes related to a biological process in a high throughput manner this review discusses plausible utilities of this technology in prostate cancer research, including definition of prostate cancer predisposition. E-mail address password forgotten password remember me. Doxycycline is a tetracycline antibiotic drug commonly used to treat infection it also has specific anti-myc, anti-tumor activity numerous studies have shown that doxycycline induces tumor apoptosis (programmed cell death) and reduces cancer cell proliferation by down-regulating myc in malignant cells. Prostate cancer (pca) is the most commonly diagnosed malignancy and the second leading cause of cancer-related death in males in western countries, including denmark, where approx 4000 men are diagnosed every year. In agreement with in vitro observations, analysis of the cancer genome atlas (tcga) data (n = 498) and a prostate cancer tissue microarray (n = 256) show that ing3 levels are higher in aggressive prostate cancers, with high levels of ing3 predicting shorter patient survival in a low ar subgroup.
A phase iii trial to study the role of neoadjuvant mcv chemotherapy combined with transurethral surgery plus cisplatin with radiation therapy for selective bladder preservation in patients with muscle-invading bladder cancer mcv: methotrexate, cisplatin, vinblastine. Background: adenocarcinoma of the prostate can present as metastatic carcinoma with no known primary prostatic origin can be confirmed in most of these cases by immunohistochemistry for prostate-specific antigen (psa) and prostate-specific acid phosphatase. An important finding was that the igs was associated with the risk of death and metastasis not only in breast cancer but also in lung cancer, prostate cancer, and medulloblastoma. The pim1 oncogene is over-expressed in human prostate cancer epithelial cells importantly, we observe that in human hyperplastic and cancerous prostate glands pim1 is also markedly elevated in prostate fibroblasts, suggesting an important role for this kinase in epithelial/stromal crosstalk the.
Germline msr1 mutations have been linked to prostate cancer in some families with prostate cancer and in sporadic prostate cancer 15, 16 however, a recent report, which investigated 163 families with familial prostate cancer, did not provide confirmatory evidence of the role of msr1 in familial prostate cancer 17. While these studies clearly support a role of filamin-a in cancer metastasis and perhaps at a later stage of metastasis, a potential role of filamin-a in cancer cell focal adhesion to the extra cellular matrix thus resisting the initial escape of cancer cells from the original sites have been recently proposed. Doxycycline vitamin c anti-cancer synergy eradicates cancer stem cells i was simply astounded by a publication appearing last week in oncotarget on anti-cancer synergy of doxycyline and vitamin c(1) this is a really huge breakthrough in cancer research, in our quest for effective non-toxic cancer treatment. However, zinc 15 mg/day for 10 years was found to decrease risk of advanced prostate cancer at the same time, epidemiological studies have illustrated a relationship between high zinc levels in breast tissue and breast cancer taken together, the research suggests that optimal zinc intake plays a role in achieving protective effects. Mutations of klf6 gene have been identified in clinical prostate cancer samples (2, 17), suggesting a tumor suppressor role for klf6 in prostate cancer indeed, decreased klf6 expression has been shown to correlate with clinical outcome in prostate cancer patients ( 23 .
High-risk prostate cancer patients, suggesting that prmt5 expression may drive the progression of prostate cancer and possibly contribute to radioresistance in support of this, we have continued to explore the underlying mechanism by which prmt5 knockdown inhibits prostate cancer cell proliferation. Background in the prostate, androgens play a crucial role in normal and cancerous growth hence the androgenic pathway has become a target of therapeutic intervention. Benign prostate hyperplasia, prostate carcinoma and prostate adenocarcinoma samples also showed increased scd expression (fig 2a) to confirm the expression of scd protein in breast cancer, we performed immunohistochemical staining of a breast cancer tissue microarray containing a total of 192 cores representing different breast cancer subtypes. Prostate cancer is associated with longer relapse-free time after radical prostatec- tomy the present tissue microarray study emphasizes the role of wnt5a protein.
However, dr chinnaiyan's team found that gene fusions also occur in an estimated 50% to 60% of prostate cancers as well as in subsets of other solid tumors we believe it is involved in early prostate cancer development and is an important therapeutic target, he says. To determine whether sox2 plays a role in the development of prostate carcinomas, we performed immunohistochemical analyses with a sox2 specific antibody in tissue microarrays containing 224 samples of human normal/paracarcinomal, hyperplasia and different clinical degrees of human prostate cancer tissues. Introduction expression of the p63 gene, a member of the p53 family (), is down-regulated in adenocarcinoma of the prostate compared with normal prostate and is used as a basal cell marker in the diagnosis of prostate cancer (.
To assess the role of grk3 in human cancer, we performed immunohistochemistry (ihc) staining of grk3 protein on a human prostate tumor tissue microarray grk3 was significantly stronger in carcinomas compared with benign prostatic hyperplasias ( p 00005, kruskal-wallis test. We evaluated the role of germline cnvs in breast cancer susceptibility, in particular those with low population frequencies (rare cnvs), which are more likely to cause disease genetic factors predisposing individuals to cancer remain elusive in the majority of patients with a familial or clinical history suggestive of hereditary breast cancer. Background the androgen receptor is a ligand-induced transcriptional factor, which plays an important role in normal development of the prostate as well as in the progression of prostate cancer to a hormone refractory state. Meta-analysis of microarray data on integrin α7 expression found low integrin α7 expression (27-fold decreased to 45-fold decreased expression) in human prostate cancer specimens from memorial sloan-kettering cancer institute and university of pittsburgh that did not metastasize but even lower expression (44-fold decreased to 61-fold.
In order to unveil the role of skp2 in the turnover of dab2ip protein, both prostate cell lines and prostate cancer specimens with a variety of molecular and cell biologic techniques were employed we demonstrated that dab2ip is regulated by skp2-mediated proteasome degradation in the prostate cell lines. Introduction prostate cancer is the second most common cancer and the second leading cause of cancer death in men in the united states androgen plays an important role not only in maintaining the function of the prostate but also in promoting the development of prostate cancer (. The prostate is a walnut-sized gland that all men have it's found below your bladder and in front of your rectum the job of the prostate is to make fluid that contains sperm ()this fluid.
Prostate cancer is the second leading cause of cancer death for men in the united states: more than one man in ten will be diagnosed in his lifetime, and one in forty-one will die of the disease. Background colorectal cancer is the third most-common cancer and the second most-common cause of cancer related death in uk although chemotherapy plays significant role in the treatment of colorectal cancer, morbidity and mortality due to drug resistance and cancer metastasis are yet to be eliminated.